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Human Genetics Seminar Series - Dr. Kasper Lage - “Functional Interpretation of Genomes Using Biological Networks"

Title: Human Genetics Seminar Series - Dr. Kasper Lage - “Functional Interpretation of Genomes Using Biological Networks"
Date & Time: Oct 12, 2015 11:00 AM - 12:00 PM
Location: Gonda Building 1st Floor Conference Room, 1357

Dr. Daniel Geschwind is hosting:

Kasper Lage, PhD
Assistant Professor, Harvard Medical School and Massachusetts General Hospital
Associate Member, The Broad Institute

"Functional interpretation of genomes using biological networks"


The recent explosion in genome-wide association studies, exome-sequencing projecta have revealed many genetic variants likely to be involved in disease processes, but the composition and function of the molecular systems they affect remain largely obscure. This limits our progress towards biological understanding and therapeutic intervention. Computational analyses that systematically integrate biological networks (i.e., networks in which genes are connected if they are functionally associated in some experimental system) with genetic data have emerged as a powerful and scalable approach to functionally interpret large genomic data sets by enabling the identification of de novo pathways perturbed in disease. This talk will highlight approaches and methods being developed in this area, and exemplify how different network-based methods have been used to analyze common and rare genetic variants to deduce the molecular networks perturbed by genetics and environment in a wide range of diseases. Furthermore, as a general model for how in silico networks can be expanded, consolidated and validated, I will show how cardiac ion-channel networks involved in human arrhythmias were elucidated and validated by combining computational modeling, GWAS, quantitative interaction proteomics, and model organisms through rigorous statistical frameworks.


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