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Research Study for Women With Regular and Irregular Menstrual Cycles

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Dr. Daniel Dumesic and his research team from the UCLA Department of Obstetrics and Gynecology are conducting a study to learn more about endocrine and metabolic conditions in women.

The team is recruiting the following three groups of women for participation:

  • Women with regular menstrual cycles 21 to 35 days apart (controls)
  • Women with irregular menstrual cycles or absent periods (i.e. periods less than every 21 days or greater than 35 days apart) and excessive body hair on upper lip, chin, chest, back, thigh, arm and/or abdomen
  • Women with a previous diagnosis of Polycystic Ovary Syndrome (PCOS) and excessive body hair on upper lip, chin, chest, back, thigh, arm and/or abdomen

Participants in all groups must meet the following criteria:

  • Caucasian AND non-Hispanic
  • Between the ages of 18 and 35
  • No use of hormones (i.e. birth control pills or a Mirena IUD) for the past 3 months
  • Not pregnant or planning to become pregnant
  • BMI between 18.5 and 25 kg/m2

All participants in the study will receive extensive free medical testing including:

  • A test for glucose metabolism (Frequently-Sampled Intravenous Glucose Tolerance Test)
  • Ovarian ultrasound to check for cysts and follicles
  • A test of ovarian hormone secretion (Follicle-Stimulating Hormone [FSH] Stimulation Test)
  • MRI and DXA scans to determine the distribution of body fat
  • Removal of a small amount of abdominal fat

• Laboratory tests and physical exams

After completing the above tests, women with regular menstrual cycles (controls) will conclude their participation in this study. Women with PCOS or irregular menstrual periods will be randomized to take the drug flutamide or a placebo (sugar pill) every day for 6 consecutive 28 day cycles and then the tests and procedures listed above will be repeated. Flutamide is a drug that temporarily blocks the action of male hormones in women.

Eligible women may receive up to $300 if they are in the control group and $840 if they are in either of the other two groups. Parking vouchers will be provided.

Please call (310) 794-2514 to learn more. In order to protect your privacy, please do not include any personal health information if you choose to e-mail us at Health4Women@mednet.ucla.edu

Posting Information
This posting expired on July 12, 2017.

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