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Department of Human Genetics - “Regulation of gene expression in the 3D genome” - Yin Shen, Ph.D.

Title: Department of Human Genetics - “Regulation of gene expression in the 3D genome” - Yin Shen, Ph.D.
Date & Time: Feb 26, 2018 11:00 AM - 12:00 PM
Location: Neuroscience Research Building (NRB) Auditorium, Room 132
 

Dr. Jake Lusis is hosting:

 

Yin Shen, Ph.D.
Assistant Professor
UCSF Institute for Human Genetics and Department of Neurology

 

Talk title: "Regulation of gene expression in the 3D genome"

 

One of the most striking findings from the ENCODE annotation is that putative regulatory sequences harbor a disproportionally large number of sequence variants associated with diverse human traits and diseases, leading to the theory that genetic lesions in the regulatory elements can substantially contribute to common complex human diseases. However, research on the role of these putative functional elements in disease pathogenesis has been hindered by a lack of knowledge of their biological function in relevant cell types.  I will discuss our approaches to functional characterize putative cis-regulatory elements and demystify how non-coding regulatory variants could contribute to human health and disease.

 

Light snack will be provided.

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