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HEADLINES
CTSI Seminar: "Metabolism Revisited" - Joshua Rabinowitz, Ph.D.
Title: CTSI Seminar: "Metabolism Revisited" - Joshua Rabinowitz, Ph.D.
Date & Time: Dec 07, 2016 12:00 PM - 1:00 PM
Location: NRB Auditorium

UCLA CFAR/AI Grand Rounds - "HIV Research: Creating Synergies to End AIDS" - Dr. Carl Dieffenbach
Title: UCLA CFAR/AI Grand Rounds - "HIV Research: Creating Synergies to End AIDS" - Dr. Carl Dieffenbach
Date & Time: Dec 09, 2016 12:00 PM - 1:00 PM
Location: 13-105CHS

CME COURSES
10th Annual UCLA Sleep CME Course: "Sleep Medicine Updates"
December 03, 2016
Neuroscience Research Building Auditorium (NRB)
UCLA Campus
Los Angeles, California
Physicians in all areas of medicine encounter patients who complain of disturbed sleep. The purpose of this course, the 10th in its series, is to provide clinicians with the knowledge needed to recognize and treat major sleep disorders likely to be encountered in their clinical practice.

The course will emphasize a practical based approach to sleep medicine across multiple specialties including primary care medicine, family practice, psychiatry, pediatrics, neurology, geriatrics and clinical psychology. The course will focus on the theories about why we sleep, and review the major sleep disorders including chronic insomnia, excessive sleepiness and narcolepsy, sleep apnea, parasomnias and restless legs syndrome (RLS).

Attendees will acquire skills needed in the recognition, evaluation and management of the major sleep disorders they are likely to encounter during routine clinical practice. A major goal of the course is to provide practitioners with current updates regarding evaluation strategies and treatment recommendations. Each presentation of the primary sleep disorder will consist of discussion of etiology, pathophysiology, diagnostic strategies and pharmacological and behavioral treatment options.

For more information visit the CME web site.
The 4th Annual UCLA Diabetes Symposium
December 03, 2016
Loews Santa Monica Beach Hotel
Santa Monica, California
Diabetes poses a major healthcare challenge. The prevalence of diabetes is rising and providers of all types are increasingly required to address glycemic control and diabetes-related complications. Treatments are broadening and newer technologies offer promise, but must also be used with care. The UCLA Annual Diabetes Symposium is a one-day CME program offering providers of varying backgrounds a chance to review optimal state-of-the-art care to the patient with diabetes. Experts in the field and its associated complications will review current best practices. Additionally, workshops aiming to address various aspects of management include updates in technology, pre-diabetes, and cardiovascular disease management.

Target Audience

The UCLA diabetes program has been designed for physicians, nurse practitioners, physician assistants, certified diabetes educators, nurse educators, dietitians, pharmacists, and other healthcare practitioners whose practice includes care of patients with diabetes.

For more information visit the CME web site.
UCLA Musculoskeletal Ultrasound Course and Hands-on Workshop 2017
January 28, 2017 to January 30, 2017
Santa Monica UCLA Hospital
Santa Monica, Caifornia
Those interested in performing MSK ultrasound in their practices, including, but not limited to radiologists, sports medicine physicians, orthopedic surgeons, rheumatologists as well as sonographers, and resident and fellow trainees seeking to improve scanning techniques and understanding of MSK sonography.

For more information visit the CME web site.
Adult Congenital Heart Disease: Quality Care in the Era of Certification and Accreditation - A Practical Approach
February 10, 2017 to February 11, 2017
UCLA Meyer and Renee Luskin Conference Center
and
Tamkin Auditorium, Ronald Reagan UCLA Medical Center
Los Angeles, California
There are now an estimated 1.5 million adults living with congenital heart disease in the United States. In order to meet the growing demand for adult congenital heart disease (ACHD) specialty care, a multi-disciplinary and comprehensive approach to program development and patient care is needed. This course highlights the components of a multidisciplinary ACHD comprehensive care center, and provides an overview of complex clinical scenarios which outlines how specialty ACHD care is provided in the U.S. based on practice guidelines and accreditation standards.

The course seeks to teach attendees about subspecialty practice standards for ACHD care to meet the life-long needs of this rapidly growing patient population. Over the past decade, the U.S. has witnessed expanding numbers of cardiology “ACHD” providers stepping up in an effort to shore up the deficits in ACHD specialty care. However, these providers vary widely with a broad spectrum of educational preparation and institutional preparation, which ultimately may impact the quality of care for ACHD patients.

For more information visit the CME web site.
Cutting Edge Interventional Solutions for Everyday Problems: What the Primary Care Physician Needs to Know
February 11, 2017
UCLA Medical Center, Santa Monica
Santa Monica Hospital Auditorium
Santa Monica, California
A variety of disease entities are seen every day in primary care practice. Interventional Radiology offers many minimally invasive treatments for these common conditions. In this course, we will present numerous interventional treatment options for neurologic, musculoskeletal, gynecologic, urologic, vascular, pulmonary, endocrine, and gastrointestinal health conditions. Ordering guidelines and up-to-date diagnostic imaging studies will be incorporated throughout the course. In addition, we will also explore the future of interventional techniques and how they may impact the treatment of today’s leading health issues.

For more information visit the CME web site.
Annual DEI/SEI Comprehensive Ophthalmology Review Course
February 09, 2017 to February 12, 2017
UCLA Stein Eye Institute - RPB Auditorium
Los Angeles, California
This four-day intensive course, aimed at ophthalmologists and trainees, will review the clinical essentials of each subspecialty in ophthalmology. It will be a clinically oriented review concentrating on the epidemiology, clinical presentation, diagnosis, and management of ophthalmologic disease; and will help prepare course participants for OKAPS, ABO, and maintenance of certification examinations. The course will cover the important clinical principles of ophthalmology and update any changes to traditional clinical protocols. It will be a review of the accepted clinical practice and will not cover research-related topics. Basic scientific mechanisms and research therapies will not be covered.

For more information visit the CME web site.
44th Annual UCLA Family Medicine Refresher Course
March 06, 2017 to March 10, 2017
Marina del Rey Marriott
Marina del Rey, California
The goal of this refresher course is to provide family physicians and other primary care providers with state-of-the-art educational experiences and accepted approaches to clinical problem-solving in both office and hospital settings.
  • The latest clinical developments of interest to family physicians
  • Practical skills workshops
  • Mini-courses providing in-depth review of selected relevant topics
  • Expanded syllabus for quick reference in your clinical practice
  • Speakers with proven ability to present relevant content useful in the family medicine context

For more information visit the CME web site.
Meeting the Challenge of Primary Care
March 15, 2017 to March 18, 2017
The Sheraton Kauai Resort
Koloa, Kauai, Hawaii
It is often said that the "common things occur most commonly" and no where is this not more true than in primary care. This four-day symposium will provide the participant with an update on common problems seen in primary care related to preventive medicine, rheumatology, internal medicine, and women's health.

A distinguished UCLA faculty group will discuss a variety of topics including hypertension, diabetes, skin disorders, headache, contraception, depression, coronary heart disease, and common rheumatologic disorders.

Target Audience

Family physicians, general practitioners, internists, nurse practitioners and physician assistants.

For more information visit the CME web site.
Fifth Annual International Retinal Imaging Symposium (IRIS V)
March 25, 2017
Tamkin Auditorium
Ronald Reagan UCLA Medical Center
Los Angeles, California
The International Retinal Imaging Symposium V will take place on Saturday, March 25, 2017 at the Ronald Reagan UCLA Medical Center and will feature a series of lectures that will focus on the latest developments in retinal imaging, including: adaptive optics, fundus autofluorescence, ultra-widefield imaging, spectral domain and swept source optical coherence tomography (OCT), and OCT angiography. This conference will include a full day of lectures by many of the world’s experts in retinal imaging who will speak on recent innovations in retinal imaging that have occurred in this rapidly advancing field.

Our world-renowned faculty will aim to familiarize course participants with the newest evolving technologies and will guide and instruct our registrants in the application of these advanced systems and in the interpretation of novel imaging findings. This will help our participants better manage their patients with macular and retinal disease and achieve better patient outcomes in their practices.

We welcome your participation at IRIS which promises to provide insight and understanding in retinal imaging and showcase the integral importance of innovative retinal imaging in the evaluation and management of retinal disease.

For more information visit the CME web site.
SEMINARS, SYMPOSIA, & TALKS
Joint Seminars in Neuroscience - Poster Presentation and Lecture
Title: Joint Seminars in Neuroscience - Poster Presentation and Lecture
Date & Time: Nov 29, 2016 4:00 PM - 5:00 PM
Location: Ackerman Union Grand Ballroom

Quantitative and Computational Biosciences - W2: Using NGS Analysis Tools - (11/29-12/1)
Title: Quantitative and Computational Biosciences - W2: Using NGS Analysis Tools - (11/29-12/1)
Date & Time: Nov 29, 2016 1:00 PM - 3:00 PM
Location: Boyer 529

Surgery Grand Rounds - “End of Life Option Act” - Neil S. Wenger, M.D., MPH
Title: Surgery Grand Rounds - “End of Life Option Act” - Neil S. Wenger, M.D., MPH
Date & Time: Nov 30, 2016 8:00 AM - 9:00 AM
Location: 73-105 CHS

Anesthesiology Grand Rounds Presents: "ASA Post-View Presentations" - Part II
Title: Anesthesiology Grand Rounds Presents: "ASA Post-View Presentations" - Part II
Date & Time: Nov 30, 2016 7:00 AM - 8:00 AM
Location: RRUMC B-130, Tamkin Auditorium

The Paul Torrens Health Forum at UCLA - Diversity in Health Professions: Successes, Challenges and What the Future Holds
Title: The Paul Torrens Health Forum at UCLA - Diversity in Health Professions: Successes, Challenges and What the Future Holds
Date & Time: Nov 30, 2016 6:00 PM - 8:00 PM
Location: Neuroscience Research Building (NRB) Auditorium, UCLA

Neurology Grand Rounds - "Regulation of the Blood-Brain Barrier in Health and Disease" - Richard Daneman, Ph.D
Title: Neurology Grand Rounds - "Regulation of the Blood-Brain Barrier in Health and Disease" - Richard Daneman, Ph.D
Date & Time: Nov 30, 2016 9:00 AM - 10:00 AM
Location: NRB Auditorium

CTSI Seminar: "Complex Traits and Simple Systems" - Leonid Kruglyak​, Ph.D.
Title: CTSI Seminar: "Complex Traits and Simple Systems" - Leonid Kruglyak​, Ph.D.
Date & Time: Nov 30, 2016 12:00 PM - 1:00 PM
Location: NRB Auditorium

CDI Special Research Seminar: “Transplant for life for children: Now, soon or never” - Stephen I. Alexander, M.D., M.P.H.
Title: CDI Special Research Seminar: “Transplant for life for children: Now, soon or never” - Stephen I. Alexander, M.D., M.P.H.
Date & Time: Nov 30, 2016 12:00 PM - 1:00 PM
Location: A2-342 MDCC (Moss Auditorium)

"The Power and Logic of Diversity" - Scott E. Page
Title: "The Power and Logic of Diversity" - Scott E. Page
Date & Time: Dec 01, 2016 4:30 PM - 6:00 PM
Location: UCLA Carnesale Commons, Palisades Room

Biomathematics - "New Rules of Inheritance in Ancient Animals" - Bo Wang, Ph.D.
Title: New Rules of Inheritance in Ancient Animals
Date & Time: Dec 01, 2016 4:00 PM - 5:00 PM
Location: A2-342 MDCC, Moss Auditorium Marion Davies Children Clinic

Seminar on Pharmaceutical Economics and Policy - "The Diffusion of AIDS Drugs into Low Income Countries; a Retrospective" - F.M Scherer
Title: Seminar on Pharmaceutical Economics and Policy - "The Diffusion of AIDS Drugs into Low Income Countries; a Retrospective" - F.M Scherer
Date & Time: Dec 01, 2016 4:30 PM - 6:30 PM
Location: Brentwood Room 16-154 CHS

UCLA Brain Mapping Seminar Series: “Speak to me: 18 years of neuroimaging in disorders of consciousness -- what have we learned?” - Martin Monti, Ph.D
Title: “Speak to me: 18 years of neuroimaging in disorders of consciousness -- what have we learned?” - Martin Monti, Ph.D
Date & Time: Dec 01, 2016 11:00 AM - 12:00 PM
Location: Neuroscience Research Building (NRB 132) 635 Charles E. Young Dr. South

MBI Thursday Seminars - “Activity-based Proteomics – Protein and Ligand Discovery on a Global Scale” - Benjamin Cravatt, Ph.D
Title: MBI Thursday Seminars - “Activity-based Proteomics – Protein and Ligand Discovery on a Global Scale” - Benjamin Cravatt, Ph.D
Date & Time: Dec 01, 2016 4:00 PM - 5:00 PM
Location: 159 Boyer Hall

ICNG: "Uncovering Neural Mechanisms of Compulsive Behavior Using Mouse Models" - Stephanie Dulawa, Ph.D.
Title: ICNG: "Uncovering Neural Mechanisms of Compulsive Behavior Using Mouse Models" - Stephanie Dulawa, Ph.D.
Date & Time: Dec 01, 2016 12:00 PM - 1:00 PM
Location: Gonda 1357 (Conference room)

"The Business Case for Diversity in Biomedical and Health Disparities" - Scott E. Page
Title: "The Business Case for Diversity in Biomedical and Health Disparities" - Scott E. Page
Date & Time: Dec 02, 2016 12:00 PM - 1:00 PM
Location: NRB Auditorium

Obstetrics and Gynecology Grand Rounds-“What's Physician Advocacy Got to Do With It?”-Pratima Gupta, M.D.
Title: Obstetrics and Gynecology Grand Rounds-“What's Physician Advocacy Got to Do With It?”-
Date & Time: Dec 02, 2016 1:15 PM - 2:15 PM
Location: RRMC B-124

HIV and CMV as Drivers of Inflammaging
Title: HIV and CMV as Drivers of Inflammaging
Date & Time: Dec 02, 2016 2:00 PM - 3:00 PM
Location: Division of Geriatrics Conference Room 10945 Le Conte Avenue, Suite 2339 (Peter Ueberroth Building)

UCLA CART Distinguished Lecture Series: "Development of Pharma Cotherapeutics for Neurodevelopmental Disorders"
Title: UCLA CART Distinguished Lecture Series: "Development of Pharma Cotherapeutics for Neurodevelopmental Disorders"
Date & Time: Dec 02, 2016 9:00 AM - 10:30 AM
Location: Gonda Neuroscience and Genetic Research Center, First Floor Conference Room

Human Genetics Seminar Series - “Of mice, men, and birds: mechanisms and evolution of recombination hotspots” - Molly Przeworski, Ph.D
Title: Human Genetics Seminar Series - “Of mice, men, and birds: mechanisms and evolution of recombination hotspots” - Molly Przeworski, Ph.D.
Date & Time: Dec 05, 2016 11:00 AM - 12:00 PM
Location: Gonda Building 1st Floor Conference Room, 1357

Big Data: Transforming Biotech and Healthcare
Title: Big Data: Transforming Biotech and Healthcare
Date & Time: Dec 05, 2016 9:00 AM - 2:00 PM
Location: CNSI at UCLA

I3T Seminar Speaker - "Regulating CD8+ T Cell Fate for Tumor Immunity" - Protul A. Shrikant, Ph.D.
Title: I3T Seminar Speaker - "Regulating CD8+ T Cell Fate for Tumor Immunity" - Protul A. Shrikant, Ph.D.
Date & Time: Dec 06, 2016 12:00 PM - 1:00 PM
Location: 53-105 CHS

Quantitative and Computational Biosciences - W6: BS-Seq - (12/6-12/8)
Title: Quantitative and Computational Biosciences - W6: BS-Seq - (12/6-12/8)
Date & Time: Dec 06, 2016 1:00 PM - 4:00 PM
Location:

Department of Human Genetics Seminar Series - "Endogenous retroviruses as catalysts of gene regulatory evolution" - Edward B. Chuong, Ph.D.
Title: Department of Human Genetics Seminar Series - "Endogenous retroviruses as catalysts of gene regulatory evolution" - Edward B. Chuong, Ph.D.
Date & Time: Dec 07, 2016 11:00 AM - 12:00 PM
Location: Gonda Building 1st Floor Conference Room, 1357

Neurology Grand Rounds - "Do Remyelination Therapies Prevent Axonal Degeneration After Inflammatory Demyelination?" - Jonah Chan, Ph.D
Title: Neurology Grand Rounds - "Do Remyelination Therapies Prevent Axonal Degeneration After Inflammatory Demyelination?" - Jonah Chan, Ph.D
Date & Time: Dec 07, 2016 9:00 AM - 10:00 AM
Location: NRB Auditorium

Orthoapedic Surgery Edgar Dawson, M.D. Memorial Lectureship - “Medical Errors - Root Cause Analysis” - Alex Vaccaro, M.D., Ph.D., MBA
Title: Orthoapedic Surgery Edgar Dawson, M.D. Memorial Lectureship - “Medical Errors - Root Cause Analysis” - Alex Vaccaro, M.D., Ph.D., MBA
Date & Time: Dec 07, 2016 7:30 AM - 8:30 AM
Location: UCLA Medical Center - Santa Monica 1250 16th Street, Santa Monica Central Wing Auditorium Room G340, 1st Floor

Team Science Training: Strategic Team Planning, Design and Communication Skills - Maritza Salazar, Ph.D.
Title: Team Science Training: Strategic Team Planning, Design and Communication Skills - Maritza Salazar, Ph.D.
Date & Time: Dec 09, 2016 11:00 AM - 2:30 PM
Location: 1-441 MRL (MacDonald Research Lab)

Obstetrics and Gynecology Grand Rounds-“Radio Frequency Ablation of Uterine Fibroids: What Women Want”-Pat Diesfeld, M.D., Bruce Lee, M.D., F.A.C.O.G.
Title: Obstetrics and Gynecology Grand Rounds-“Radio Frequency Ablation of Uterine Fibroids: What Women Want”-Pat Diesfeld, M.D., Bruce Lee, M.D., F.A.C.O.G.
Date & Time: Dec 09, 2016 1:15 PM - 2:15 PM
Location: RRMC B-124

Department of Human Genetics Seminar Series - "Causes and consequences of our gut microbial differences" - Federico E. Rey, Ph.D.
Title: Department of Human Genetics Seminar Series - "Causes and consequences of our gut microbial differences" - Federico E. Rey, Ph.D.
Date & Time: Dec 12, 2016 11:00 AM - 12:00 PM
Location: Gonda Building 1st Floor Conference Room, 1357

BruinTech Career Day
Title: BruinTech Career Day
Date & Time: Dec 13, 2016 9:00 AM - 12:00 PM
Location: Bruin Reception Room, Ackerman Union

Vascular Biology Seminar Series - "Going with the Flow in Atherosclerosis: From Vascular Mechanobiology to Nanomedicine"- Hanjoong Jo, Ph.D., FAHA, FAPS, FBMES
Title: Vascular Biology Seminar Series - "Going with the Flow in Atherosclerosis: From Vascular Mechanobiology to Nanomedicine"- Hanjoong Jo, Ph.D., FAHA, FAPS, FBMES
Date & Time: Dec 13, 2016 4:00 PM - 5:00 PM
Location: Boyer Hall Room 159

NHLBI Small Biz Hangout: Taking Care of Business - Managing SBIR/STTR Grants
Title: NHLBI Small Biz Hangout: Taking Care of Business - Managing SBIR/STTR Grants
Date & Time: Dec 13, 2016 11:00 AM - 12:00 PM
Location:

Neurology Grand Rounds - "Brain Repair After Stroke" - Steven Cramer, M.D.
Title: Neurology Grand Rounds - "Brain Repair After Stroke" - Steven Cramer, M.D.
Date & Time: Dec 14, 2016 9:00 AM - 10:00 AM
Location: NRB Auditorium

CDI Scientific Seminar Series: “Immunobiology of Vitamin D” - John Adams, M.D.
Title: CDI Scientific Seminar Series: “Immunobiology of Vitamin D” - John Adams, M.D.
Date & Time: Dec 15, 2016 12:00 PM - 1:00 PM
Location: A2-342 MDCC (Moss Auditorium)

NHLBI Small Biz Hangout: Adopting New Technologies - A System’s Perspective
Title: NHLBI Small Biz Hangout: Adopting New Technologies - A System’s Perspective
Date & Time: Dec 16, 2016 10:00 AM - 11:00 AM
Location:

ANNOUNCEMENTS
UCLA's Online CME - Expiring Activities
UCLA’s Online CME activities are only available for one year after the date of their release, and some will be expiring soon!
Upcoming Events with noted scholar and author Dr. Scott E. Page
We are pleased to announce two special events with noted scholar and author
Drop-In Statistical Consults at UCLA
The UCLA CTSI Biostatistics, Epidemiology and Research Design Program provides integrated services and biostatistical support. Services include (1) contemporary data analysis methodology consultation, implementation, and epidemiology expertise; (2) the best available clinical data management software; (3) study design and grant preparation assistance; and (4) bioinformatics/computational biology data analysis.
CDI Seminar Series 2016-2017: Join Us for Third Thursdays!
The UCLA Children's Discovery and Innovation Institute (CDI) promotes Child Health Research programs to connect all research and training activities related to improving children's health and health care. It encourages multidisciplinary child health research and research training at UCLA across the spectrum of basic, translational, and health services research.
UCLA CTSI K Workshop, 2/9/17 8:30-4pm (Early registration deadline: 5PM on December 19, 2016)
The UCLA Clinical and Translational Science Institute (CTSI) will be holding an all-day workshop for junior investigators who have applied, are applying, or thinking about applying for a NIH K/Career Development Award. The UCLA CTSI Workforce Development Program is offering this special opportunity to junior faculty at CTSI partnered institutions (Cedars-Sinai, CDU, LA Biomed Harbor-UCLA, and UCLA) to learn how to prepare successful K applications. Breakfast and lunch will be served.
Drop-In for Grant Application Support with CTSI's Grants Submission Unit
Get Help on Your Grant Application.
RESEARCH STUDY RECRUITMENT
Research Study for Women With Regular and Irregular Menstrual Cycles
Dr. Daniel Dumesic and his research team from the UCLA Department of Obstetrics and Gynecology are conducting a study to learn more about endocrine and metabolic conditions in women.
Prediabetic study for overweight/obese adults
This study investigates the effect of an amino acid supplement on glucose levels for non-smoking prediabetic adults (20-50 years of age) who have a BMI between 27-40 and a waist circumference >40in (male) or >35in (female). The study will last approximately 12 weeks and will include a compensation of $200 upon completion of the study. For more information, please call 310-206-8292.
Undiagnosed Diseases Network: Accepting new patients at UCLA
NIH funded research study for patients with undiagnosed and/or rare diseases
Healthy Children 8 to 12 Years Old Needed for a Study of Brain Development
Healthy Children 8 to 12 Years Old Needed for a Study of Brain Development
UCLA Duchenne Muscular Dystrophy Study
Our study is seeking to evaluate the brain anatomy and functioning of boys 7 to 15 years old with DMD.
Do You Suspect That Your Child May Have ADHD?
Do You Suspect That Your Child May Have ADHD?
UCLA Research Study on Anorexia Nervosa
The purpose of this brain imaging study is to understand the effects of anxiety on reward responsiveness in female adolescents (13-19) diagnosed with anorexia nervosa, and how this interaction predicts clinical outcome after an intensive treatment program.
Does Your Teen Have Mild Anxiety?
The purpose of this brain imaging study is to understand the effects of anxiety on reward responsiveness in female adolescents with mild anxiety and also females diagnosed with anorexia nervosa.
Children Ages 8-14 Needed for Brain Imaging Study
Currently recruiting children ages 8-14 without autism spectrum disorder to study brain development in children with ASD. Children can earn up to $190 and receive a picture of their brain!
FUNDING OPPORTUNITIES
The Collaboratory Fellowship Program
Funding opportunity for postdoctoral fellowships in computational biology and bioinformatics.
CTSI Catalyst Awards
UCLA Clinical and Translational Science Institute (CTSI) is inviting applications for Catalyst Grants beginning November 1, 2016. Catalyst Grants support team-building activities that advance translational science and promote collaborations across disciplines and CTSI institutions. Awards will range from $100 to $5,000, depending on the nature and scope of the project.
UC CAI Technology Development Award, Pre-Application Due
UC CAI anticipates awarding multiple Technology Development Grants for development of drugs; devices, including wireless; diagnostics; and tools that address heart, lung and sleep and blood disorders
UCLA CTSI TL1 Summer Fellowship Program for Professional Students - Application Deadline February 1, 2017
The UCLA CTSI TL1 Summer Fellowship Program (SFP) is for health professional students (medical, nursing and dental) during their training. The program will provide each individual with early exposure to the practice of interdisciplinary, community-partnered, translational (clinical implementation or public health), or health services research in urban underserved communities.